微生物的社交通信之群体感应机制简介 每日消息

微生物和人一样会借助于语言进行交流。微生物交流的主要方式之一是群体感应(quorum sensing,QS)。微生物的生长并不是一个简单的微生物个体在环境中获得营养物质、生长繁殖的过程,它涉及增殖细胞在定期传代培养期间引起的细胞群体密度的波动,伴随着细胞代谢,生长速率和运动的改变,导致细胞的微环境和宏观环境发生相应的变化


(资料图片仅供参考)

[2] Parsek M R, Greenberg E P. Sociomicrobiology: the connections between quorum sensing and biofilms[J]. Trends in Microbiology,2005,13(1):27~33.

[3] Fuqua W C, Winans S C, Greenberg E P. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators[J]. J Bacteriol,1994,176(2):269~275.

[4] Thompson J A, Oliveira R A, Djukovic A, et al. Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota[J]. Cell Reports,2015,10(11):1861~1871.

[5] Wu S, Liu J, Liu C, et al. Quorum sensing for population-level control of bacteria and potential therapeutic applications[J]. Cellular and Molecular Life Sciences,2020,77(7):1319~1343.

[6] Prescott R D, Decho A W. Flexibility and Adaptability of Quorum Sensing in Nature[J]. Trends in Microbiology,2020,28(6):436~444.

[7] Xue T, Zhao L, Sun H, et al. LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing[J]. Cell Res,2009,19(11):1258~1268.

[8] Vrla G D, Esposito M, Zhang C, et al. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa[J]. PLOS Pathogens,2020,16(9):e1008867.

[9] Barrasso K, Watve S, Simpson C A, et al. Dual-function quorum-sensing systems in bacterial pathogens and symbionts[J]. PLOS Pathogens,2020,16(10):e1008934.

[10] Yajima A, Katsuta R, Shimura M, et al. Disproof of the Proposed Structures of Bradyoxetin, a PutativeBradyrhizobium japonicum Signaling Molecule, and HMCP, a PutativeRalstonia solanacearum Quorum-Sensing Molecule[J]. Journal of Natural Products,2021,84(2):495~502.

[11] Cornelis P. Putting an end to the Pseudomonas aeruginosa IQS controversy[J]. MicrobiologyOpen (Weinheim),2020,9(2):e962.

作者:菌子兰

排版: 小益君

校正:小栗子、小歪

关键词: